Dan Mullen, Chris Steele

With the MAC and PAC-12 returning to the fold, BetRivers.com has more college football Week 10 odds than any other week this season. For what seems like the fourteenth year in a row, the expectations are high for Southern Cal, while Oregon looks to retool on the fly. There’s also the matter of a mighty big game in South Bend, IN between the Trevor Lawrence-less Clemson Tigers and the Notre Dame Fighting Irish.

Longtime sports broadcaster and gambling expert Michael Jenkins is here to run through the notable college football Week 10 odds, including some betting stats and ATS numbers to help you make the right call.

College Football Week 10 Odds:

Arizona State (0-0) at #20 USC (0-0). 12:00 p.m. ET
Moneyline: USC -400, Arizona State +300
Spread: USC -10.5
Over/Under: 58.5 points

Another year, and more high expectations for USC, which will once again go with Kedon Slovis at quarterback after he tossed an impressive 30 touchdowns last season. The Trojans also welcome defensive coordinator Todd Orlando, who was fired from the same job at Texas.

Arizona State’s Herm Edwards has added two more NFL names to his coaching staff, with Marvin Lewis and Antonio Pierce running the show as co-defensive coordinators. The Sun Devils are 5-2 ATS in their last seven in Southern California.

Click here for the full list of USC-Arizona State odds.

#8 Florida (3-1) at Georgia #5 (4-1). 3:30 p.m. ET
Moneyline: Georgia -152, Florida +125
Spread: Georgia -3.5
Over/Under: 52.5 points

Florida Head Coach Dan Mullen dressed like Darth Vader for his postgame press conference after the Gators handed Missouri a 41-17 defeat on Halloween, but will he harness enough of the dark side to beat Georgia? It probably depends on the play of quarterback of Kyle Trask, who threw four touchdown passes last week. The Dawgs bring one of the best defenses in the country to the World’s Largest Cocktail Party and held Kentucky to only 229 yards last week.

Click here for the full list of Florida-Georgia odds.

#7 Texas A&M (4-1) at South Carolina (2-3). 7:00 p.m. ET
Moneyline: Texas A&M -335, South Carolina +255
Spread: Texas A&M -9.5
Over/Under: 59.5 points

The Aggies have been one of the bigger surprises in college football, going 4-1 with their only loss coming to Alabama, and Kellen Mond is a big reason why. The senior quarterback threw four touchdown passes last Saturday in a 42-31 victory against Arkansas.

The Gamecocks received a 52-24 thrashing at the hands of LSU last time out, but they generally play better at home and have had an extra seven days to prepare. The Under is 4-0 in Sound Carolina’s last four games after a bye.

Click here for the full list of Texas A&M-South Carolina odds.

#1 Clemson (7-0) at #4 Notre Dame (6-0). 7:30 p.m. ET
Moneyline: Clemson -286, Notre Dame +180
Spread: Clemson -5.5
Over/Under: 51.5 points

For the second consecutive week, Clemson starting quarterback Trevor Lawrence is out because of COVID-19 concerns, so D.J. Uiagalelei will again get the start. He rallied the Tigers from an early deficit last week to give Clemson a 34-28 comeback win against Boston College.

Notre Dame returns home to South Bend after a two-game road trip, and the Irish continue to rely on their ground game, which churned out 227 yards rushing and three touchdowns in a victory against Georgia Tech. The Fighting Irish are 5-0 against the number in their last five games as a home underdog.

Click here for the full list of Clemson-Notre Dame odds.

Stanford (0-0) at #12 Oregon (0-0). 7:30 p.m. ET
Moneyline: Oregon -385, Stanford +285
Spread: Oregon -10.5
Over/Under: OFF

Stanford rolls into Autzen Stadium coming off a 4-8 record in 2019 and down a significant number of players. Davis Shaw’s bunch want to pound the football, but they must improve on rushing numbers that ranked 11th in the Pac-12 last season. The Cardinal are 0-4 ATS in their last four.

Oregon will reload with NFL talent, and the Tyler Shough era begins in Eugene now that Justin Herbert is taking snaps for the Los Angeles Chargers. However, CJ Verdell returns and is aiming for his third straight 1,000-yard season.

Click here for the full list of Stanford-Oregon odds.