2021 NCAA Tournament: First Round odds, predictions

The 2021 NCAA Tournament bracket is finalized and the schedule is ready, which means it’s time to take a look at the opening lines and NCAA Tournament first round odds. BetRivers.com is proud to provide a wide variety of NCAA Tournament first round odds, futures, futures, props, teasers, and team markets.

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The 2021 NCAA Tournament begins on Thursday, March 18 with the First Four. The NCAA Tournament First Round takes place on Friday, March 19, and Saturday, March 20. The Second Round takes place on Sunday, March 21, and Monday, March 22.

The Sweet 16 will take place on Saturday, March 27 and Sunday, March 28. The Elite Eight will take place on Monday, March 29, and Tuesday, March 30. The 2021 NCAA Tournament will wrap up with the Final Four and National Championship, held on Saturday, April 3, and Monday, April 5. The entire 2021 NCAA TOurnament will be held in the greater Indianapolis area.

Click here for a printable 2021 NCAA Tournament Bracket.

Click here for the complete list of NCAA Tournament first round odds, tournament futures and prop bets.

Read below for the NCAA Tournament First Round odds and opening lines, as of Sunday, March 14.

RELATED: FIRST ROUND UPSET PICKS

NCAA Tournament First Round Odds: FIRST FOUR

#16 Mount St. Mary’s (12-10) vs. #16 Texas Southern (16-8)

Date/Time/TV: Thursday, 3/18. 5:10 p.m. ET (TruTV)
Moneyline: Texas Southern -134 ML, Mt. St. Mary’s +112 ML
Spread: Texas Southern -2
Over/Under: 132.5 points

Click here for the full list of Mt. St. Marys-Texas Southern odds.

#11 Wichita State (16-5) vs. #11 Drake (25-4)

Date/Time/TV: Thursday, 3/18. 6:27 p.m. ET (TBS)
Moneyline: Wichita State -132 ML, Drake +112 ML
Spread: Wichita State -2
Over/Under: 139 points

Click here for the full list of Wichita State-Drake odds.

#16 Norfolk State (16-7) vs. #16 Appalachian State (17-11)

Date/Time/TV: Thursday, 3/18. 8:40 p.m. ET (TruTV)
Moneyline: Appalachian State -124 ML, Norfolk State ML +104
Spread: Appalachian State -1.5
Over/Under: 135.5 points

Click here for the full list of Norfolk State-Appalachian State odds.

#11 Michigan State (15-12) vs. #11 UCLA (17-9)

Date/Time/TV: Thursday, 3/18. 9:57 p.m. ET. (TBS)
Moneyline: Michigan State -114 ML, UCLA -105 ML
Spread: Michigan State -1
Over/Under: 137.5 points

Click here for the full list of Michigan State-UCLA odds.

NCAA Tournament First Round Odds: WEST REGION

#1 Gonzaga (26-0) vs. #16 Norfolk State/#16 Appalachian State

Date/Time/TV: Saturday, March 20. 9:20 p.m. ET (TBS)
Moneyline: TBD
Spread: TBD
Over/Under: TBD

#8 Oklahoma (15-10) vs. #9 Missouri (16-9)

Date/Time/TV: Saturday, March 20. 7:25 p.m. ET (TNT)
Moneyline: Oklahoma -132 ML, Missouri +112 ML
Spread: Oklahoma -2
Over/Under: 141 points

Click here for the full list of Oklahoma-Missouri odds.

#5 Creighton (20-8) vs. #12 UC-Santa Barbara (22-4)

Date/Time/TV: Saturday, March 20. 3:30 p.m. ET (TruTV)
Moneyline: Creighton -315 ML, UCSB +255
Spread: Creighton -7
Over/Under: 140 points

Click here for the full list of Creighton-UCSB odds.

#4 Virginia (18-6) vs. #13 Ohio (16-7)

Date/Time/TV: Saturday, March 20. 7:15 p.m. ET (TruTV)
Moneyline: Virginia -560 ML, Ohio +425 ML
Spread: Virginia -10
Over/Under: 131 points

Click here for the full list of Virginia-Ohio odds.

#6 Southern Cal (22-7) vs. #11 Wichita State/#11 Drake

Date/Time/TV: Saturday, March 20. 4:30 p.m. ET (TNT)
Moneyline: TBD
Spread: TBD
Over/Under: TBD

#3 Kansas (20-8) vs. #14 Eastern Washington (16-7)

Date/Time/TV: Saturday, March 20. 1:15 p.m. ET (TBS)
Moneyline: Kansas -770 ML, Eastern Washington +550 ML
Spread: Kansas -11.5
Over/Under: 142 points

Click here for the full list of Kansas-Eastern Washington odds.

#7 Oregon (20-6) vs. #10 VCU (19-7)

Date/Time/TV: Saturday, March 20. 9:57 p.m. ET (TNT)
Moneyline: Oregon -265 ML, VCU +215 ML
Spread: Oregon -6
Over/Under: 137 points

Click here for the full list of Oregon-VCU odds.

#2 Iowa (21-8) vs. #15 Grand Canyon (17-6)

Date/Time/TV: Saturday, March 20. 6:25 p.m. ET (TBS)
Moneyline: Iowa -1667 ML, Grand Canyon +900 ML
Spread: Iowa -15
Over/Under: 144.5 points

Click here for the full list of Iowa-Grand Canyon odds.

NCAA Tournament First Round Odds: EAST REGION

#1 Michigan (20-4) vs. #16 Mt. St. Mary’s/#16 Texas Southern

Date/Time/TV: Saturday, March 20. 3:00 p.m. ET (CBS)
Moneyline: TBD
Spread: TBD
Over/Under: TBD

#8 LSU (18-9) vs. #9 St. Bonaventure (16-4)

Date/Time/TV: Saturday, March 20. 1:45 p.m. ET (TNT)
Moneyline: LSU -114 ML, St. Bonaventure -105 ML
Spread: LSU -1
Over/Under: 145 points

Click here for the full list of LSU-St. Bonaventure odds.

#5 Colorado (22-8) vs. #12 Georgetown (13-12)

Date/Time/TV: Saturday, March 20. 12:15 p.m. ET (CBS)
Moneyline: Colorado -220 ML, Georgetown +180 ML
Spread: Colorado -5
Over/Under: 139 points

Click here for the full list of Colorado-Georgetown odds.

#4 Florida State (16-6) vs. #13 UNC Greensboro (21-8)

Date/Time/TV: Saturday, March 20. 12:45 p.m. ET (TruTV)
Moneyline: FSU -770 ML, UNCG +550 ML
Spread: Florida State -11.5
Over/Under: 145.5

Click here for the full list of Florida State-UNC Greensboro odds.

#6 BYU (20-6) vs. #11 Michigan State/#11 UCLA

Date/Time/TV: Saturday, March 20. 9:40 p.m. ET (CBS)
Moneyline: TBD
Spread: TBD
Over/Under: TBD

#3 Texas (19-7) vs. #14 Abilene Christian (23-4)

Date/Time/TV: Saturday, March 20. 9:50 p.m. ET (TruTV)
Moneyline: Texas -455 ML, Abilene Christian +350 ML
Spread: Texas -9
Over/Under: 139.5 points

Click here for the full list of Texas-Abilene Christian odds.

#7 UConn (15-7) vs. #10 Maryland (16-13)

Date/Time/TV: Saturday, March 20. 7:10 p.m. ET (CBS)
Moneyline: UConn -134 ML, Maryland +112 ML
Spread: UConn -2
Over/Under: 130.5 points

Click here for the full list of UConn-Maryland odds.

#2 Alabama (24-6) vs. #15 Iona (12-5)

Date/Time/TV: Saturday, March 20. 4:00 p.m. ET (TBS)
Moneyline: Alabama -2000 ML, Iona +1050 ML
Spread: Alabama -16
Over/Under: 143.5 points

Click here for the full list of Alabama-Iona odds.

NCAA Tournament First Round Odds: MIDWEST REGION

#1 Illinois (23-6) vs. #16 Drexel (12-7)

Date/Time/TV: Friday, March 19. 1:15 p.m. ET (TBS)
Moneyline: Illinois -10000 ML, Drexel +1900 ML
Spread: Illinois -22
Over/Under: 145 points

Click here for the full list of Illinois-Drexel odds.

#8 Loyola-Chicago (24-4) vs. #9 Georgia Tech (17-8)

Date/Time/TV: Friday, March 19. 4:00 p.m. ET (TBS)
Moneyline: Loyola-Chicago -143 ML, Georgia Tech +120
Spread: Loyola-Chicago -2.5
Over/Under: 127.5 points

Click here for the full list of Loyola-Georgia Tech odds.

#5 Tennessee (18-8) vs. #12 Oregon State (17-12)

Date/Time/TV: Friday, March 19. 4:30 p.m. ET (TNT)
Moneyline: Tennessee -420 ML, Oregon State +330 ML
Spread: Tennessee -8.5
Over/Under: 134 points

Click here for the full list of Tennessee-Oregon State odds.

#4 Oklahoma State (20-8) vs. #13 Liberty (23-5)

Date/Time/TV: Friday, March 19. 6:25 p.m. ET (TBS)
Moneyline: Oklahoma State -500 ML, Liberty +380 ML
Spread: Oklahoma State -9.5
Over/Under: 144.5 points

Click here for the full list of Oklahoma State-Liberty odds.

#6 San Diego State (23-4) vs. #11 Syracuse (16-9)

Date/Time/TV: Friday, March 19. 9:40 p.m. ET (CBS)
Moneyline: SDSU -114 ML, Syracuse -105 ML
Spread: SDSU -1
Over/Under: 137.5 points

Click here for the full list of Oklahoma State-Syracuse odds.

#3 West Virginia (18-9) vs. #14 Morehead State (23-7)

Date/Time/TV: Friday, March 19. 9:50 p.m. ET (TruTV)
Moneyline: WVU -835 ML, Morehead State +575 ML
Spread: WVU -12
Over/Under: 137.5 points

Click here for the full list of West Virginia-Morehead State odds.

#7 Clemson (16-7) vs. #10 Rutgers (15-11)

Date/Time/TV: Friday, March 19. 9:20 p.m. ET (TBS)
Moneyline: Rutgers -124 ML, Clemson +104 ML
Spread: Rutgers -1.5
Over/Under: 129 points

Click here for the full list of Clemson-Rutgers odds.

#2 Houston (24-3) #15 Cleveland State (19-7)

Date/Time/TV: Friday, March 19. 7:15 p.m. ET (TruTV)
Moneyline: Houston -3335 ML, Cleveland State +1300 ML
Spread: Houston -19
Over/Under: 135 points

Click here for the full list of Houston-Cleveland State odds.

NCAA Tournament First Round Odds: SOUTH REGION

#1 Baylor (22-2) vs. #16 Hartford (15-8)

Date/Time/TV: Friday, March 19. 3:30 p.m. ET (TruTV)
Moneyline: TBD
Spread: Baylor -25.5
Over/Under: 141.5 points

Click here for the full list of Baylor-Hartford odds.

#8 North Carolina (18-10) vs. #9 Wisconsin (17-12)

Date/Time/TV: Friday, March 19. 7:10 p.m. ET (CBS)
Moneyline: UNC -132, Wisconsin +112
Spread: UNC -2
Over/Under: 139 points

Click here for the full list of North Carolina-Wisconsin odds.

#5 Villanova (16-6) vs. #12 Winthrop (23-1)

Date/Time/TV: Friday, March 19. 9:57 p.m. ET (TNT)
Moneyline: Villanova -265 ML, Winthrop +215 ML
Spread: Villanova -6
Over/Under: 138.5 points

Click here for the full list of Villanova-Winthrop odds.

#4 Purdue (18-9) vs. #13 North Texas (17-9)

Date/Time/TV: Friday, March 19. 7:25 p.m. ET (TNT)
Moneyline: Purdue -385 ML, North Texas +300 ML
Spread: Purdue -8
Over/Under: 125.5 points

Click here for the full list of Purdue-North Texas odds.

#6 Texas Tech (17-10) vs. #11 Utah State (20-8)

Date/Time/TV: Friday, March 19. 1:45 p.m. ET (TNT)
Moneyline: Texas Tech -200 ML, Utah State +165 ML
Spread: Texas Tech -4.5
Over/Under: 133 points

Click here for the full list of Texas Tech-Utah State odds.

#3 Arkansas (22-6) vs. #14 Colgate (14-1)

Date/Time/TV: Friday, March 19. 12:45 p.m. ET (TruTV)
Moneyline: Arkansas -435 ML, Colgate +340 ML
Spread: Arkansas -9
Over/Under: 157.5 points

Click here for the full list of Arkansas-Colgate odds.

#7 Florida (14-9) vs. #10 Virginia Tech (15-6)

Date/Time/TV: Friday, March 19. 12:15 p.m. ET (CBS)
Moneyline: Virginia Tech -113 ML, Florida -106 ML
Spread: Virginia Tech -0.5
Over/Under: 137.5 points

Click here for the full list of Florida-Virginia Tech odds.

#2 Ohio State (21-9) vs. #15 Oral Roberts (16-10)

Date/Time/TV: Friday, March 19. 3:00 p.m. ET (CBS)
Moneyline: Ohio State -2000 ML, Oral Roberts +1050 ML
Spread: Ohio State -16.5
Over/Under: 154.5 points

Click here for the full list of Ohio State-Oral Roberts odds.